Author

B. Sharma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 2 Bioengineering· 1 Physiology· 1

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

R. Dries· 3 shared R. E. George· 3 shared H. Huang· 2 shared K. Pervushin· 2 shared M. Krajewska· 2 shared A. Bhatnaagar· 1 shared A. Crespo· 1 shared A. J. MacNeil· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCancer Biology

R. Dries

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The MYCN 5' UTR as a therapeutic target in neuroblastoma

M. P. Volegova, L. E. Brown, U. Banerjee, R. Dries, B. Sharma, A. Kennedy, J. A. Porco, R. E. George

This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.

bioRxiv · Feb 20, 2024Cancer Biology

Antibody targeting of aging damaged isoDGR-protein doubles lifespan in a mouse model of chronic inflammation

P. Kalailingam, K.-H. Mohd-Kahliab, S. C. Ngan, R. Iyappan, E. Melekh, T. Lu, G. W. Zien, B. Sharma, T. Guo, A. J. MacNeil, R. E. K. Macpherson, E. L. Tsiani, D. D. O'Leary, K. L. Lim, I. H. Su, , S. K. Sze

This paper shows that targeting aging-damaged isoDGR-proteins with antibodies extends lifespan in a mouse model of chronic inflammation.

bioRxiv · Mar 11, 2023 · PreprintBiochemistry

Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

J. Nyman, T. Denize, Z. Bakouny, C. Labaki, B. M. Titchen, K. Bi, S. N. Hari, J. Rosenthal, N. Mehta, B. Jiang, B. Sharma, K. Felt, R. Umeton, D. A. Braun, S. Rodig, , E. M. Van Allen

The paper uses spatially aware deep learning to identify tumor heterogeneity patterns in kidney cancer, revealing distinct states associated with different histological subtypes.

bioRxiv · Jan 18, 2023Cancer Biology

Impaired baroreceptor reflex sensitivity in pelvic suspension rats is associated with sympathovagal imbalance but not with carotid artery structural change

A. Bhatnaagar, K. K. Deepak, A. Roy, A. K. Anil, B. Sharma, A. Singh, R. Netam

This study shows that 15 days of hindlimb unloading in rats reduces baroreflex sensitivity and heart rate variability, but does not cause structural changes in carotid arteries.

bioRxiv · Sep 2, 2022 · PreprintPhysiology

Complete sequences of the velvet worm slime proteins reveal that slime formation is enabled by disulfide bonds and intrinsically disordered regions

Y. Lu, B. Sharma, W. L. Soon, S. Xiangyan, T. Zhao, Y. T. Lim, R. M. Sobota, S. Hoon, G. Pilloni, A. Usadi, K. Pervushin, A. Miserez

The paper determines the complete sequences of velvet worm slime proteins and identifies disulfide bonds and intrinsically disordered regions as key to slime self-assembly.

bioRxiv · Feb 18, 2022Bioengineering

Cell lineage as a predictor of immune response in neuroblastoma

S. Sengupta, S. Das, A. Crespo, B. Miller, B. Sharma, S. Zhang, R. Dries, H. Huang, M. Krajewska, D. N. Debruyne, L. Soriano, M. A. Cohen, R. Versteeg, R. Jaenisch, S. Spranger, , R. E. George

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

bioRxiv · Jan 29, 2021Cancer Biology

Conjugates of neuroprotective chaperone L-PGDS provide MRI contrast for detection of amyloid β-rich regions in live Alzheimer's Disease mouse model brain

B. Sharma, J. Grandjean, M. Phillips, A. Kumar, F. Mandino, L.-Y. Yeow, V. Nandwana, V. P. Dravid, X. Bengang, S. Lim, K. Pervushin

This study conjugates the neuroprotective chaperone L-PGDS with magnetic nanoparticles to enhance MRI contrast for detecting amyloid β-rich regions in Alzheimer's Disease mouse models.

bioRxiv · Mar 8, 2020Biochemistry

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

M. Krajewska, R. Dries, A. V. Grassetti, S. Dust, Y. Gao, H. Huang, B. Sharma, D. S. Day, N. Kwiatkowski, M. Pomaville, O. Dodd, E. Chipumuro, T. Zhang, A. L. Greenleaf, G.-C. Yuan, , R. E. George

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.

bioRxiv · Nov 30, 2018Cancer Biology