Ciliary tip actin dynamics regulate the cadenceof photoreceptor disc formation
R. Megaw, A. Moye, Z. Zhang, F. Newton, F. McPhie, L. C. Murphy, L. McKie, F. He, M. K. Jungnickel, A. von Kriegsheim, L. Machesky, T. G. Wensel, P. Mill
This study shows that actin dynamics at photoreceptor cilia tips regulate disc formation, and RPGR mutations disrupt this process, leading to retinal degeneration.
bioRxiv · Nov 10, 2022Cell Biology