F. He

Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction

This study examines the evolution of the resistome in Salmonella Gallinarum during its transition to endemicity, revealing localized mobilome-driven resistance profiles.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Global thermal tolerance of freshwater invertebrates and fish

The paper compiles a thermal tolerance database for freshwater fish and invertebrates, including 5000+ records from 800+ species, to assess thermal risks under current and future environmental conditions.

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.

Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms

This study identifies metabolic alterations in MPN platelets, showing that alpha-ketoglutarate supplementation reduces hyperreactivity and inflammation.

pathCLIP: Detection of Genes and Gene Relations from Biological Pathway Figures through Image-Text Contrastive Learning

The paper introduces pathCLIP, a system that identifies genes and gene relations from biological pathway figures using image-text contrastive learning, outperforming single-modality approaches.

Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography

The paper uses cryo-electron tomography to reveal structural features of photoreceptor cilia in mouse retinas, including the basal body, Y-links, and ciliary necklace.

Time-resolved cryo-EM of G protein activation by a GPCR

This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

Ciliary tip actin dynamics regulate the cadenceof photoreceptor disc formation

This study shows that actin dynamics at photoreceptor cilia tips regulate disc formation, and RPGR mutations disrupt this process, leading to retinal degeneration.

Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

The paper develops a proteomics-based classifier to predict lymph node metastasis in T1 colorectal cancer using protein expression patterns and machine learning.

A latitudinal pattern of plant leaf-associated bacterial community assembly

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

Circular RNA circGT1C1 drives gastric TIC self-renewal to initiate gastric tumorigenesis and metastasis

The paper was withdrawn due to poor experimental design and irreproducible results.

SER: an R package to compute environmental regime over a certain time period

SER computes environmental regimes over time periods to improve understanding of environmental impacts on ecological communities and other fields.

4D Cell-Condensate Bioprinting

This paper introduces a 4D bioprinting method to create shape-morphing cell condensate bilayers with predefined geometries, demonstrating its use in forming complex shapes like 'C' and helix-shaped cartilage-like tissues from hMSCs.

Staphylococcus aureus nt5 gene contributes to bacterial infection ability to form kidney abscess

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

This study uses whole genome sequencing of Hodgkin and Reed Sternberg cells to reconstruct the temporal evolution of classic Hodgkin lymphoma, identifying key mutations and structural variants.

Structure Determination of Inactive-State GPCRs with a Universal Nanobody

This paper uses nanobodies to determine cryo-EM structures of inactive-state GPCRs, achieving resolutions comparable to X-ray crystallography and providing insights into ligand binding.

Insights into the susceptibility of rice to a floral disease

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

Assembly of chromosome-scale and allele-aware autotetraploid genome of the Chinese alfalfa cultivar Zhongmu-4 and identification of SNP loci associated with 27 agronomic traits

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

The patterns of vascular plant discoveries in China

The paper analyzes patterns of vascular plant discoveries in China, finding that socio-economic factors and species traits influence discovery rates and that southwest China harbors the most undiscovered species.

Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

The untapped potential of conservation journals to promote freshwater biodiversity

This paper analyzes cover images of conservation journals to show freshwater ecosystems are underrepresented, suggesting journals could promote freshwater biodiversity by featuring more freshwater species and habitats.

Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity

The paper identifies cis-regulatory variants affecting gene expression plasticity in three Arabidopsis species under dehydration stress, showing lineage-specific selective pressures on regulatory changes.

Analytical models for β-diversity and the power-law scaling of β-deviation

The paper derives analytical models for β-diversity to clarify its interpretation, extend its application to occurrence data, and show power-law scaling of β-deviation with sampling effort.

Novel non-transposable-element regulation patterns of KZFP family reveal new drivers of its rapid evolution

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

Polygenic adaptation of rosette growth in Arabidopsis thaliana populations

This study investigates the genetic and environmental factors influencing growth rate variation in Arabidopsis thaliana, finding polygenic adaptation and environmental plasticity as key drivers.

AI-aided design of novel targeted covalent inhibitors against SARS-CoV-2

The paper designs novel covalent inhibitors against SARS-CoV-2 using a deep Q-learning network and fragment-based drug design, generating 47 lead compounds available in a public repository.

Global Screening of Sentrin-Specific Protease Family Substrates in SUMOylation

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic beta-cells

This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.