TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
J. Verhoeven, K. A. Jacobs, F. Rizzollo, F. Lodi, Y. Hua, J. Pozniak, A. N. Srinvasan, D. Houbaert, G. Shankar, S. More, M. B. Schaaf, N. Dubroja Lakic, M. Ganne, J. Lamote, J. Van Weyenbergh, , P. Agostinis
This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.
bioRxiv · Apr 21, 2023Cancer Biology