P. Agostinis

Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters

The paper introduces PRINCESS, a novel biosensor that simultaneously detects membrane contact sites and measures associated Ca2+ dynamics using splitFAST technology.

Human ADA2 deficiency is characterized by the absence of an intracellular hypoglycosylated form of adenosine deaminase 2

The paper identifies an intracellular hypoglycosylated form of ADA2 absent in DADA2 patients, linking its absence to reduced deaminase activity and variant pathogenicity.

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

The IRE1 Inhibitor KIRA6 Curtails The Inflammatory Trait Of Immunogenic Anticancer Treatments By Targeting HSP60 Independent Of IRE1

The paper shows KIRA6 reduces inflammation from immunogenic cancer treatments by targeting HSP60, not through IRE1 inhibition.

Downregulation of miR-17-92 cluster by PERK fine-tunes unfolded protein response mediated apoptosis

The paper shows that PERK-mediated repression of miR-17-92 cluster promotes ER stress-induced apoptosis through NRF2.