Author

D. Houbaert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

G. Bergers· 2 shared G. Shankar· 2 shared L. Boon· 2 shared M. Agrawal· 2 shared M. Ganne· 2 shared P. Agostinis· 2 shared S. More· 2 shared A. N. Srinvasan· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersImmunology

G. Bergers

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

D. Houbaert, A. P. Nikolakopoulos, O. Mece, K. Jacobs, J. Roels, G. Shankar, M. Agrawal, S. More, M. Ganne, K. Rillaerts, L. Boon, M. Swoboda, M. Nobis, L. Mourao, F. M. Bosisio, , P. Agostinis

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

bioRxiv · Jul 17, 2023Immunology

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

J. Verhoeven, K. A. Jacobs, F. Rizzollo, F. Lodi, Y. Hua, J. Pozniak, A. N. Srinvasan, D. Houbaert, G. Shankar, S. More, M. B. Schaaf, N. Dubroja Lakic, M. Ganne, J. Lamote, J. Van Weyenbergh, , P. Agostinis

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

bioRxiv · Apr 21, 2023Cancer Biology