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Loss of the systemic vitamin A transporter RBPR2 affects the quantitative balance between chromophore and opsins in visual pigment synthesis

This study shows that loss of RBPR2 affects retinoid homeostasis and visual pigment synthesis, leading to visual function defects in mice under vitamin A deficiency.

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

Enhancing Recovery from Gut Microbiome Dysbiosis and Alleviating DSS-Induced Colitis in Mice with a Consortium of Rare Short-Chain Fatty Acid-Producing Bacteria

Klebsiella pneumoniae Co-infection Leads to Fatal Pneumonia in SARS-CoV-2-infected Mice

This study shows that co-infection with SARS-CoV-2 and Klebsiella pneumoniae in mice leads to severe pneumonia and higher mortality.

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

This paper shows PARP12 inhibits replication of a Mac1 mutant coronavirus in some cell and tissue types but not all, suggesting other PARPs also contribute to antiviral defense.

Toll-like receptor 7 (TLR7)-mediated antiviral response protects mice from lethal SARS-CoV-2 infection

This study shows that TLR7 signaling protects mice from lethal SARS-CoV-2 infection by enhancing antiviral responses and reducing inflammation.

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

A novel biopolymer for mucosal adjuvant against respiratory pathogens

This study evaluates a novel biopolymer, GC, as a nasal mucosal adjuvant for respiratory vaccines, showing improved immune response and survival in mice compared to Addavax.

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

Effective interferon (IFN)-lambda treatment regimen to control lethal MERS-CoV infection in mice

This study identifies an effective two-dose IFN-lambda regimen that protects mice from lethal MERS-CoV infection by reducing viral load and inflammation.