In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
A. Kaushik, L. K. Burroughs, A. Tarangelo, M. Ragavan, C.-Y. Wu, X. Li, K. Ahumada, V. T. Tcheuyap, F. Saatchi, Q. Do, C. Yong, T. Rosales, C. Stevens, A. D. Rao, B. Faubert, , R. J. DeBerardinis
The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.
bioRxiv · Oct 31, 2022Cancer Biology