Cancer BiologybioRxiv
In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
A. Kaushik, L. K. Burroughs, A. Tarangelo…·R. J. DeBerardinis
The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.
DOI 10.1126/sciadv.abp8293