Author

A. Tarangelo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Z. Long· 2 shared S. J. Dixon· 2 shared A. D. Rao· 1 shared A. He· 1 shared A. Kaushik· 1 shared B. Faubert· 1 shared B. S. P. Slusher· 1 shared C. Stevens· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

J. Z. Long

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Author profile →

3 papers

Recent·Most cited

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

J. Rodencal, N. Kim, V. Li, A. He, M. Lange, J. He, A. Tarangelo, Z. T. Schafer, J. Olzmann, J. Sage, J. Z. Long, S. J. Dixon

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

bioRxiv · Jul 19, 2023 · PreprintCancer Biology

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

A. Kaushik, L. K. Burroughs, A. Tarangelo, M. Ragavan, C.-Y. Wu, X. Li, K. Ahumada, V. T. Tcheuyap, F. Saatchi, Q. Do, C. Yong, T. Rosales, C. Stevens, A. D. Rao, B. Faubert, , R. J. DeBerardinis

The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.

bioRxiv · Oct 31, 2022Cancer Biology

Nucleotide Biosynthesis Links Glutathione Metabolism to Ferroptosis Sensitivity

A. Tarangelo, J. T. Kim, J. Z. Long, S. J. Dixon

The paper shows that p53 inhibition of nucleotide metabolism reduces ferroptosis by preserving glutathione levels through RNR suppression.

Life Science Alliance · Jan 24, 2022Peer-reviewedCancer Biology