C.-Y. Wu

The heparin-binding domain of VEGF165 directly binds to integrin αvβ3 and plays a critical role in signaling.

This study identifies the heparin-binding domain of VEGF165 as critical for integrin αvβ3 binding and signaling, showing its role in mitogenic activity.

A shift in the host web occupancy of dew-drop spiders associated with genetic divergence in the Southwest Pacific

This study examines genetic differentiation in the spider Argyrodes bonadea across the Southwestern Pacific, finding that host specialization drives genetic variation while generalist strategies promote broad dispersal and gene flow.

Successive responses of three coral holobiont components (coral hosts, symbiotic algae, and bacteria) to daily temperature fluctuations

This study examines how coral hosts, symbiotic algae, and bacteria respond to daily temperature fluctuations and continuous warming, finding that diurnal fluctuations may reduce heat stress and bacterial response changes.

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.

Anti-PF4 (heparin-independent)/PF4 complex induces allosteric activation of integrins αIIbβ3 and αvβ3, a potential mechanism of vaccine-induced thrombotic thrombocytopenia (VITT) and autoimmune diseases

This paper shows that the PF4/anti-PF4 complex activates integrins αIIbβ3 and αvβ3 through site 2 binding, suggesting a mechanism for VITT and autoimmune diseases.

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

Effect of mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell-cell fusion function

This study examines how mutations in the SARS-CoV-2 spike protein affect its stability, cleavage, and ability to mediate cell-cell fusion.

Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

This study shows that DEGS1/Ifc promotes exosome production by enhancing intraluminal vesicle formation and inhibiting autophagic degradation of multivesicular endosomes in Drosophila.

Monodisperse drops templated by 3D-structured microparticles

This paper demonstrates a method to create uniform sub-nanoliter compartments using 3D-structured microparticles, enabling stable monodisperse drops without specialized equipment.

Formation of uniform reaction volumes using concentric amphiphilic microparticles

The paper develops a method to create uniform microscale reaction compartments using amphiphilic microparticles, enabling scalable and multiplexed assays with high sensitivity.

Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein

This paper introduces a sonogenetic method using an engineered auditory-sensing protein to control cellular activities with ultrasound, showing it can stimulate neurons in deep brain regions non-invasively.

An E3 ubiquitin ligase from Nicotiana benthamiana targets the replicase of Bamboo mosaic virus and restricts its replication

The paper identifies NbUbE3R1, an E3 ubiquitin ligase in Nicotiana benthamiana, which restricts Bamboo mosaic virus replication by targeting its replicase.