Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy
A. Villunger, G. Karbon, F. Schuler, M. Haschka, M. Drach, R. Sotillo, S. Geley, D. C. J. Spierings, A. Tijhuis, F. Foijer
The paper investigates the effects of chronic SAC activation in mice, finding it causes bone marrow aplasia and intestinal atrophy, with BIM playing a critical role in gastrointestinal cell death.
bioRxiv · Sep 8, 2023 · PreprintCell Biology