ROS signalling requires uninterrupted electron flow and is lost during ageing in flies
C. Graham, R. Stefanatos, A. E. H. Yek, R. V. Spriggs, S. H. Y. Loh, A. Huerta Uribe, T. Zhang, L. M. Martins, O. D. K. Maddocks, F. Scialo, A. Sanz
The paper shows that ROS-RET signalling requires uninterrupted electron flow through the ETC and is lost during ageing in flies, leading to persistent mtROS production and reduced stress adaptation.
bioRxiv · Aug 18, 2021 · PreprintPhysiology