Chemotherapy induces a YAP1-dependent fetal conversion to human Colorectal Cancer cells that is predictive of poor patient outcome
L. Sole, T. Lobo-Jarne, A. Villanueva, A. Vert, Y. Guillen, I. Sangrador, A. Barbachano, J. Lop, M. Guix, M. Salido, B. Bellosillo, R. Garcia-Romero, M. Garrido, J. Gonzalez, M. Martinez-Iniesta, , L. Espinosa
The paper shows that sublethal chemotherapy induces a YAP1-dependent fetal phenotype in colorectal cancer cells, which predicts poor patient outcomes.
bioRxiv · Apr 8, 2021 · PreprintCancer Biology