Ribosome association primes the stringent factor Rel for recruitment of deacylated tRNA to ribosomal A-site
H. Takada, M. Roghanian, J. Caballero-Montes, K. Van Nerom, S. Jimmy, P. Kudrin, F. Trebini, R. Murayama, G. Akanuma, A. Garcia-Pino, V. Hauryliuk
The paper reveals how RelA/SpoT Homolog factor Rel in Bacillus subtilis detects amino acid starvation by interacting with deacylated tRNA on the ribosome, triggering (p)ppGpp synthesis.
bioRxiv · Jan 17, 2020 · PreprintBiochemistry