Author

A. Garcia-Pino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell signaling & trafficking· 3 Organism:E. coli· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

V. Hauryliuk· 7 shared G. C. Atkinson· 6 shared T. Kurata· 5 shared H. Takada· 4 shared T. Brodiazhenko· 4 shared T. Tenson· 4 shared M. Roghanian· 3 shared A. Cepauskas· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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7 shared papersMicrobiology

V. Hauryliuk

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Mechanism of phage sensing and abortion by toxin-antitoxin-chaperone systems

T. Mets, T. Kurata, K. Ernits, M. J. O. Johansson, S. Z. Craig, G. M. Evora, J. A. Buttress, R. Odai, K. Coppieters't Wallant, J. A. Nakamoto, L. Shyrokova, A. A. Egorov, C. R. Doering, T. Brodiazhenko, M. T. Laub, , V. Hauryliuk

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

bioRxiv · Feb 24, 2024 · PreprintMicrobiology

The structural basis of hyperpromiscuity in a core combinatorial network of Type II toxin-antitoxin and related phage defence systems

K. Ernits, C. K. Saha, T. Brodiazhenko, B. Chouhan, A. Shenoy, J. J. Duque-Pedraza, V. Bojar, J. A. Nakamoto, T. Kurata, A. Egorov, L. Shyrokova, M. J. O. Johansson, T. Mets, A. Rustamova, J. Dzigurski, , G. C. Atkinson

The paper identifies a core combinatorial network of Type II toxin-antitoxin systems, reveals their structural basis for hyperpromiscuity, and validates new TA systems with functional annotations.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

Direct activation of an innate immune system in bacteria by a viral capsid protein

T. Zhang, H. Tamman, K. Coppieters't Wallant, T. Kurata, M. LeRoux, S. Srikant, T. Brodiazhenko, A. Cepauskas, A. Talavera, C. Martens, G. C. Atkinson, V. Hauryliuk, A. Garcia-Pino, M. T. Laub

This study identifies a bacterial immune system that directly senses a viral capsid protein through a toxin-antitoxin system, revealing a PAMP-like mechanism for innate immunity in bacteria.

bioRxiv · May 30, 2022 · PreprintMicrobiology

RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

T. Kurata, T. Brodiazhenko, S. R. A. Oliveira, M. Roghanian, K. J. Turnbull, O. Bulvas, H. Takada, R. Pohl, A. Garcia-Pino, D. Rejman, T. Tenson, G. C. Atkinson, V. Hauryliuk

The paper investigates how four RSH toxins inhibit bacterial growth by pyrophosphorylating tRNA, disrupting protein synthesis and amino acid sensing.

bioRxiv · Apr 30, 2021Microbiology

The C-terminal RRM/ACT domain is crucial for fine-tuning the activation of 'long' RelA-SpoT Homolog enzymes by ribosomal complexes

H. Takada, M. Roghanian, V. Murina, I. Dzhygyr, R. Murayama, G. Akanuma, G. C. Atkinson, A. Garcia-Pino, V. Hauryliuk

This study shows that the RRM domain in long RSH enzymes is essential for proper ribosome-mediated activation, preventing excessive (p)ppGpp production and cytotoxicity.

bioRxiv · Jan 23, 2020Biochemistry

Ribosome association primes the stringent factor Rel for recruitment of deacylated tRNA to ribosomal A-site

H. Takada, M. Roghanian, J. Caballero-Montes, K. Van Nerom, S. Jimmy, P. Kudrin, F. Trebini, R. Murayama, G. Akanuma, A. Garcia-Pino, V. Hauryliuk

The paper reveals how RelA/SpoT Homolog factor Rel in Bacillus subtilis detects amino acid starvation by interacting with deacylated tRNA on the ribosome, triggering (p)ppGpp synthesis.

bioRxiv · Jan 17, 2020 · PreprintBiochemistry

A widespread toxin-antitoxin system exploiting growth control via alarmone signalling

S. Jimmy, C. K. Saha, C. G. Stavropoulos, S. R. A. Oliveira, T. Kurata, A. Koh, A. Cepauskas, H. Takada, T. Tenson, H. Strahl, A. Garcia-Pino, V. Hauryliuk, G. C. Atkinson

The paper identifies toxin-antitoxin systems in bacteria using alarmone signalling, showing how SASs function as toxins and their antitoxins counteract them.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology

Regulation of (p)ppGpp hydrolysis by a conserved archetypal regulatory domain

S. Ronneau, J. Caballero-Montes, A. Mayard, A. Garcia-Pino, R. Hallez

This study investigates the role of the ACT domain in SpoT-mediated (p)ppGpp hydrolysis in Caulobacter crescentus and shows its interaction with phosphorylated EIIANtr.

bioRxiv · Jan 31, 2018Microbiology