H. Takada

A role for the S4-domain containing protein YlmH in ribosome-associated quality control in Bacillus subtilis

This study identifies YlmH as a novel RQC factor in B. subtilis, showing it can replace RqcP in polyalanine tail addition and is conserved in bacteria lacking RqcP.

Resolution of ribosomal stalling by ABCF ATPases YfmR and YkpA/YbiT

This study identifies the roles of ABCF ATPases YfmR and YkpA/YbiT in resolving ribosomal stalling during protein synthesis in Bacillus subtilis.

Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR

The paper characterizes genome-encoded ABCF proteins in Gram-positive bacteria, showing their roles in intrinsic antibiotic resistance and revealing structural and regulatory mechanisms.

Synthetic oxepanoprolinamide iboxamycin is highly active against human pathogen Listeria monocytogenes

This study shows synthetic iboxamycin is effective against Listeria monocytogenes, overcoming resistance mechanisms, and highlights potential resistance development.

Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics

This paper presents cryo-EM structures of PoxtA bound to the ribosome, revealing its mechanism of antibiotic resistance by perturbing tRNA and altering nascent chain conformation.

RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

The paper investigates how four RSH toxins inhibit bacterial growth by pyrophosphorylating tRNA, disrupting protein synthesis and amino acid sensing.

Trophic transfer of microplastics enhances tissue accumulation of chemical additives in fish

This study compares chemical accumulation in fish from direct microplastic exposure versus indirect exposure through prey, finding higher concentrations from prey-mediated ingestion.

Structural basis of resistance to lincosamide, streptogramin A, and pleuromutilin antibiotics by ABCF ATPases in Gram-positive pathogens

The paper determines the structures of ARE ABCF-ribosome complexes from three Gram-positive bacteria and proposes a model for antibiotic resistance mechanisms.

Structural basis for bacterial ribosome quality control

This study identifies RqcH and YabO as factors mediating C-terminal tailing in Bacillus subtilis through cryo-EM structures showing their role in tRNA movement without mRNA or small subunit.

The C-terminal RRM/ACT domain is crucial for fine-tuning the activation of 'long' RelA-SpoT Homolog enzymes by ribosomal complexes

This study shows that the RRM domain in long RSH enzymes is essential for proper ribosome-mediated activation, preventing excessive (p)ppGpp production and cytotoxicity.

Ribosome association primes the stringent factor Rel for recruitment of deacylated tRNA to ribosomal A-site

The paper reveals how RelA/SpoT Homolog factor Rel in Bacillus subtilis detects amino acid starvation by interacting with deacylated tRNA on the ribosome, triggering (p)ppGpp synthesis.

A widespread toxin-antitoxin system exploiting growth control via alarmone signalling

The paper identifies toxin-antitoxin systems in bacteria using alarmone signalling, showing how SASs function as toxins and their antitoxins counteract them.

Relationship between ocean area and incidence of anthropogenic debris ingested by longnose lancetfish (Alepisaurus ferox)

This study examines plastic ingestion in longnose lancetfish across different ocean areas, finding higher incidence in Sagami Bay compared to the North Pacific and Indian Ocean.

Elimination of ribosome inactivating factors improves the efficiency of Bacillus subtilis and Saccharomyces cerevisiae cell-free translational systems

This study shows that disrupting genes encoding ribosome inactivating factors improves the activity of cell-free translational systems in Bacillus subtilis and Saccharomyces cerevisiae.