Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment
D. Ganguly, M. O. Schmidt, M. Coleman, T.-V. Ngo, N. Sorrelle, A. T. Dominguez, J. Toombs, C. Lewis, Y. Fang, F. V. Mora, D. Gallego-Ortega, A. Wellstein, R. A. Brekken
This study identifies pleiotrophin as a driver of a pro-metastatic immune niche in breast cancer, showing its role in immune suppression and metastasis, and highlights its potential as a therapeutic target.
bioRxiv · May 2, 2022Cancer Biology