Cancer BiologybioRxiv
Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment
D. Ganguly, M. O. Schmidt, M. Coleman…·R. A. Brekken
This study identifies pleiotrophin as a driver of a pro-metastatic immune niche in breast cancer, showing its role in immune suppression and metastasis, and highlights its potential as a therapeutic target.
DOI 10.1084/jem.20220610