GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection
Ming Yang, Fuyun Bian, Xue Feng…·Yang Hu
This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.
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Stanford UniversityORCID 0000-0002-9624-9665Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Ming Yang, Fuyun Bian, Xue Feng…·Yang Hu
This study shows that GPX4 overexpression in RGCs promotes optic nerve regeneration and neuroprotection in glaucoma models.
Dong Liu, Hannah C. Webber, Fuyun Bian…·Yang Hu
This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.
Ala Moshiri, Fang Fang, Pei Zhuang…·Yang Hu
This paper establishes a rhesus macaque model of glaucomatous neurodegeneration using silicone oil injection, showing RGC death, optic nerve degeneration, and functional deficits similar to human glaucoma.