Fang Chen

Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccines

This study identifies structural features of HCV E2 glycoprotein recognized by germline B cell receptors and evaluates strategies to enhance germline antibody interactions.

Deciphering the Genetic Architecture of Sorghum Grain Oil Content via Lipidome-Integrated Genome-Wide Association Analysis

This study integrates lipidomics with GWAS in sorghum to identify genetic loci associated with grain oil content and composition, revealing new insights into lipid metabolism and its genetic regulation.

Asymmetric partition of the O-GlcNAcome in mitosis ensures binary cell fate decision

The paper shows that the O-GlcNAcome segregates asymmetrically during Drosophila neuroblast mitosis, influencing daughter cell fate.

scFPC-DE: Robust Differential Expression Analysis Along Single Cell Trajectories via Functional Principal Component Analysis

scFPC-DE identifies temporally differentially expressed genes along single-cell trajectories by modeling gene expression as functions of pseudotime and using functional principal component analysis to capture shared covariance structures.

Integrative metabolome-genome analysis reveals the genetic architecture of metabolic diversity in sorghum grain

This study integrates metabolomics and genomics in sorghum to uncover the genetic basis of metabolic diversity, identifying millions of SNP-metabolite associations and gene clusters.

Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

This paper demonstrates that PCR-free whole genome sequencing using the DNBSEQ platform and machine learning variant calling significantly reduces InDel errors and improves variant calling performance.

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

PALM-Seq simultaneously sequences cell-free long and small RNA, identifying pregnancy-related RNAs and sample-specific signatures in plasma, amniotic fluid, leukocytes, and placentas.

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

The paper analyzes single-cell RNA-seq data from human embryos to compare gene expression between males and females, identifying differences in sex chromosome activation and dosage compensation during early development.

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

The paper introduces scCAT-seq, a method to simultaneously assay chromatin accessibility and transcriptome in single cells, and demonstrates its application in human pre-implantation embryos to reveal regulatory heterogeneity.

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation

This study uses single-cell RNA-seq to analyze transcriptome dynamics during human early neural differentiation, identifying novel transcription factors and regulatory elements involved in the process.

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

This study reports two cases of maternal malignancies detected incidentally during noninvasive prenatal tests in Asian women, showing concordant genome disruption patterns between tumor samples and NIPT results.