Molecular BiologyCell Death DiscoveryPeer-reviewed
Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegeneration
Marta Marzullo, Giulia Romano, Claudia Pellacani…·Fabian M. Feiguin
The paper shows that Su(var)3-9 increases H3K9 methylation on the TDP-43 promoter with age, leading to reduced TDP-43 expression and neurodegeneration in Drosophila, mice, and humans.
10 citations