J. Deng

The development of ecological systems along paths of least resistance

The paper shows that ecological systems develop in a sequenced order from fast-to slow-growing taxa due to environmental resistance minimization, supported by theoretical and empirical evidence.

Enrichment of glycoRNAs using galactose oxidase, hydrazide chemistry, and glycosidase digestion

The paper develops and optimizes methods to enrich and identify glycoRNAs, demonstrating efficient digestion and preservation techniques for studying their role in immune responses and disease.

Riluzole reverses blood-testis barrier loss to rescue chemotherapy induced male infertility by binding to TRPC

This study shows riluzole restores blood-testis barrier function and rescues chemotherapy-induced male infertility in mice by targeting TRPC5.

A novel genetic fluorescent reporter to visualize mitochondrial nucleoids

The paper introduces a genetic fluorescent reporter, mt-HI-NESS, to visualize mitochondrial nucleoids in live cells without affecting mtDNA replication or expression.

The catalytic mechanism of the RNA methyltransferase METTL3

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

Modulation of Allostery with Multiple Mechanisms by Hotspot Mutations in TetR

This study evaluates allostery hotspot mutations in TetR using molecular dynamics simulations to understand their effects on allosteric coupling and functional free energy landscapes.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1-mutant lung cancer

The paper identifies CD38 as a therapeutic target in LKB1-mutant lung cancer through in vivo metabolomics and shows that targeting CD38 inhibits tumor growth.

On the limits to invasion prediction using coexistence outcomes

This study examines the limits of predicting invasion outcomes from coexistence outcomes using a Lotka-Volterra framework, showing varying degrees of translatability between different ecological dynamics.

Integrating metabolic scaling and coexistence theories

This paper integrates metabolic scaling and coexistence theories to explain community-level patterns in population abundance and biomass density across body sizes.

Excessive apoptosis of naïve T cells resulting hyperactivation as a cause of mammalian aging

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

Variable organization of symbiont-containing tissue across planthoppers hosting different heritable endosymbionts

The paper examines the organization of symbiont-containing tissues in planthoppers with different endosymbionts, identifying seven symbiont localization types and seven bacteriome organization types.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

Understanding the impact of third-party species on pairwise coexistence

The paper investigates how third-party species affect pairwise coexistence probabilities in multispecies systems under environmental uncertainty, showing that their impact varies across different pairs.

Dermal nerve growth factor is increased in prurigo nodularis compared to atopic dermatitis

This study compares the inflammatory, neuropathic, and structural pathways in prurigo nodularis (PN) to atopic dermatitis (AD), finding increased NGF and ECM remodeling in PN.

Circulating plasma IL-13 and periostin are dysregulated type 2 inflammatory biomarkers in prurigo nodularis: a cluster analysis

This study identifies elevated plasma IL-13 and periostin as type 2 inflammatory biomarkers in prurigo nodularis using clustering analysis of cytokine profiling.

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

This study links TOP1MT deficiency and the P193L variant to mtDNA release and cGAS-STING activation, contributing to autoimmune disease susceptibility.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

RUNIMC: An R-based package for imaging mass cytometry data analysis and pipeline validation

The paper introduces RUNIMC, an R package for imaging mass cytometry data analysis, comparing an unbiased approach with a biased method using synthetic and clinical datasets.

Sex-dependent Lupus Ruminococcus blautia gnavus strain induction of zonulin-mediated intestinal permeability and autoimmunity

This study shows that Lupus-associated Ruminococcus blautia gnavus strains increase intestinal permeability and autoimmunity, which can be reversed by larazotide acetate.

DAB2IP inhibits p53 ubiquitin-mediated degradation by competitively binding to GRP75 and suppresses tumor malignancy in colon cancer

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

Chromatin Accessibility Reveals Potential Prognostic Value of the Peak Set Associated with Smoking History in Patients with Lung Adenocarcinoma

The paper identifies ATAC-seq peaks associated with smoking history in lung adenocarcinoma that correlate with patient survival and are linked to key oncogenic pathways.

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

Effect of cutting depth during sugarcane harvest on root characteristics and yield

This study finds that cutting sugarcane at 5 cm depth increases root fresh weight, volume, and fine root development, leading to higher cane yield compared to 0 or 10 cm cutting depths.

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

This study identifies calcitriol, the active form of vitamin D, as a potent inhibitor of SARS-CoV-2, suggesting its potential as a prophylactic agent against COVID-19.

Heat Shock Protein 27 versus Estrogen Therapy for Post-Menopausal Atherosclerosis: Rethinking Mechanisms of Cholesterol Lowering

This study compares the effects of HSP25 vaccination and estrogen therapy on atherogenesis in post-menopausal mice, finding that both reduce plaque but through different mechanisms involving PCSK9 and LDLR.

Heat Shock Protein 27 Immune Complex Altered Signaling and Transport (ICAST): Novel Mechanisms of Attenuating Inflammation

The paper shows that HSP27 immune complexes reduce inflammation and cholesterol uptake by modulating TLR4 and scavenger receptors in macrophages.