ImmunologybioRxivPreprint
Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning
Diego A. Figueroa, Juan Pablo Vega, Andrés Hernández‐Oliveras…·Álvaro Lladser
This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.