BiochemistrybioRxivPreprint
Molecular architecture of a membrane-spanning hormone acyltransferase required for metabolic regulation
Maria B. Campaña, Flaviyan Jerome Irudayanathan, Tasha R. Davis…·James L. Hougland
The paper presents a structural model of GOAT, an MBOAT enzyme, using co-evolutionary constraints and computational modeling validated by biochemistry, revealing a novel acylation mechanism within a transmembrane channel.
DOI 10.1101/556233