MicrobiologybioRxivPreprint
Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance
Ophélie d’Udekem d’Acoz, Fong Hue, Tianyi Ye…·Rodrigo Reyes-Lamothe
This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.
DOI 10.1101/2023.09.05.556435