Cancer BiologybioRxiv
Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease
G. Assante, S. Chandrasekaran, S. Ng…·N. A. Youngson
This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.