C. H. Chung

This study uses mathematical models to determine the timing and mechanism of cetuximab resistance in HNSCC using tumor volume data from xenografts.

VALIS automates registration of immunohistochemistry and immunofluorescence images, enabling spatial analysis of whole slide images with low error and minimal computational time.

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

The paper develops a method to estimate immune cell content in tumors using scRNA-seq reference data, showing improved performance over existing methods in distinguishing immune subtypes.