S. Ng

Characterization of the Cannabis sativa glandular trichome epigenome

This study maps histone modifications and integrates transcriptomics in Cannabis sativa glandular trichomes to link chromatin states to specialized metabolism gene expression.

Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

Transcription Factor Dynamics in Cross-Regulation of Plant Hormone Signaling Pathways

The paper constructs a cross-regulation network of plant hormone signaling pathways by analyzing transcription factor activity and dynamic regulatory models in Arabidopsis seedlings.

Establishment of cell transcriptional identity during seed germination

This study maps the temporal changes in cell-type specific gene expression during Arabidopsis seed germination, revealing a shared initial transcriptional state followed by distinct regulatory programs.

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

This study shows STING activation promotes Tr1 cell development during malaria by enhancing IFNB gene transcription and modulates this pathway with ruxolitinib.

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

This study shows that targeted degradation of PCNA via biodegraders leads to more effective anti-proliferative effects and programmed cell death compared to stoichiometric inhibition.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

STUB1 is an intracellular checkpoint for interferon gamma sensing

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

Discovery and biosynthesis of clostyrylpyrones from the obligate anaerobe Clostridium roseum

The paper discovers a new family of natural products, clostyrylpyrones, from Clostridium roseum and proposes their polyketide synthase-based biosynthesis mechanism.

bioPROTACs establish RAS as a degradable target and provide novel RAS biology insights

The paper demonstrates that RAS proteins can be degraded using bioPROTACs and provides insights into the functional consequences of RAS degradation and mutant susceptibility.

bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)

This paper introduces bioPROTACs as intracellular biologics for targeted protein degradation, demonstrating their effectiveness against PCNA with rapid degradation and functional effects.

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.