S. Chandrasekaran

Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock

This study investigates how phosphorylation, disorder, and phase separation regulate the behavior of Frequency (FRQ) in the fungal circadian clock of Neurospora crassa.

ROP16-mediated activation of STAT6 facilitates encystment of type III Toxoplasma gondii in neurons

This study identifies ROP16-mediated phosphorylation of STAT6 as a host factor facilitating strain-specific encystment of Toxoplasma gondii in neurons.

Constraint-based modeling identifies metabolic vulnerabilities during the epithelial to mesenchymal transition

The paper uses constraint-based modeling to identify metabolic dependencies during EMT in A549 cells, revealing isoform-specific metabolic vulnerabilities.

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

The paper develops a deep learning model to predict CRISPR-Cas13d guide RNA efficiency and identifies novel orthologs with improved specificity and reduced toxicity for RNA targeting.

Mechanistic insight into light-dependent recognition of Timeless by Drosophila cryptochrome

The paper investigates how light affects CRY-TIM binding in Drosophila using a new assay and shows that flavin redox state and histidine residues control this interaction.

Interdomain linkers regulate histidine kinase activity by controlling subunit interactions

This study shows that interdomain linkers in CheA regulate kinase activity by modulating subunit interactions and domain dynamics.

Longitudinal monitoring of individual infection progression in Drosophila melanogaster

This study introduces a bioluminescent imaging method to monitor pathogen load in individual Drosophila melanogaster over time without sacrificing animals.

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

Accelerating Prediction of Chemical Shift of Protein Structures on GPUs

The paper accelerates chemical shift prediction for large protein complexes using GPU acceleration, reducing computation time from 14 hours to 46.71 seconds.

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.