Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease
G. Assante, S. Chandrasekaran, S. Ng, A. Tourna, C. H. Chung, K. A. Isse, C. Filippi, A. Dhawan, M. Liu, S. G. Rozen, M. Hoare, P. Campbell, J. W. O. Ballard, N. Turner, M. J. Morris, , N. A. Youngson
This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.
bioRxiv · Jul 22, 2021Cancer Biology