The chemical synthesis of knob domain antibody fragments
A. Macpherson, J. R. Birtley, R. J. Broadbridge, K. Brady, Y. Tang, C. Joyce, K. Saunders, G. Bogle, J. Horton, S. Kelm, R. D. Taylor, R. J. Franklin, M. D. Selby, M. Laabei, T. Wonfor, , A. D. G. Lawson
This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.
bioRxiv · Jun 16, 2021 · PreprintBiochemistry