C. Joyce

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC (Hereditary Leiomyomatosis and Renal Cell Cancer) and renal cancer

The paper quantifies phenotypic specificity of rare FH variants in HLRCC and renal cancer using likelihood ratios from clinical and population data.

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes

This study identifies multiple broadly neutralizing antibody clonotypes in HIV-1 infected pediatric twins using BCR sequencing, showing ongoing development in one twin but not the other.

The chemical synthesis of knob domain antibody fragments

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

Assessment of the pollution incident performance of water and sewerage companies in England

This study analyzes pollution incident data from water and sewerage companies in England to assess performance variations and reporting practices.

Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

The paper compares antibody repertoires between a humanized rodent (OmniRat) and humans using high-throughput sequencing, identifying similarities and differences in diversity and recombination features.

Female lower urinary tract microbiota do not correspond to IC/PBS symptoms: a case-controlled study

This study investigates whether differences in female urinary microbiota correlate with IC/PBS symptoms and finds no significant differences between patients and controls.