A. MacPherson

Innate immune system signaling and CD11b+CD11c+CD103+ cell migration to the brain underlie changes in mouse behavior after microbial colonization.

This study identifies innate immune signaling and CD11b+CD11c+CD103+ cell migration to the brain as mechanisms linking microbial colonization to behavioral changes in mice.

The Untapped Potential of Tree Size in Reconstructing Evolutionary and Epidemiological Dynamics

This paper explores the use of tree size in phylodynamic inference, showing it provides additional insights for diversification questions not captured by shape or branch lengths alone.

Component specific responses of the microbiomes to common chemical stressors in the human food chain

This study examines how chemical stressors affect microbiomes across different food chain components, finding component-specific responses and shifts in microbial composition and stability.

Maternal diet and gut microbiome composition modulate early life immune development

This study shows that maternal diet and gut microbiome composition affect early immune development in offspring by altering microbial colonization and immune gene expression.

Density-dependent selection during range expansion affects expansion load in life-history traits

The paper examines how density-dependent selection during range expansion interacts with allele surfing to affect genetic load and life-history trait evolution.

Parental population range expansion before secondary contact promotes heterosis

The paper shows that historical parental population expansion before secondary contact can lead to heterosis in hybrids by reducing the negative effects of Bateson-Dobzhansky-Muller incompatibilities.

Neo-sex chromosome evolution shapes sex-dependent asymmetrical introgression barrier

This study examines how neo-sex chromosome evolution creates sex-dependent asymmetrical introgression barriers in a hybrid swarm of Drosophila species.

The chemical synthesis of knob domain antibody fragments

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

Fundamental identifiability limits in molecular epidemiology

This study identifies fundamental limits in phylodynamic inference, showing that epidemiological parameters cannot be uniquely determined from viral phylogenetic data alone.

The allosteric modulation of Complement C5 by knob domain peptides

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

A General Birth-Death-Sampling Model for Epidemiology and Macroevolution

The paper unifies various birth-death-sampling models into a general framework, showing they are special cases of a more general model and provides a method to derive likelihoods for complex scenarios.

Insights into the role of C3d dimers in B cell activation and Staphylococcal immune evasion

This study identifies C3d dimers' role in B cell activation and their potential to promote anergy, contributing to Staphylococcus aureus immune evasion and autoimmunity.

Feedback Between Coevolution and Epidemiology Can Help or Hinder the Maintenance of Genetic Variation in Host-Parasite Models

The paper examines how ecological and epidemiological feedbacks influence genetic variation maintenance in host-parasite coevolution models, finding coevolution rarely outperforms neutral drift.

Coevolution does not slow the rate of loss of heterozygosity in a stochastic host-parasite model with constant population size

The paper models host-parasite coevolution in a finite population and finds that matching-alleles coevolution reduces genetic variation rather than maintaining it.