Author

S. Kelm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

J. Rosenau· 3 shared A. Kovaltsuk· 2 shared C. M. Deane· 2 shared J. Snowden· 2 shared M. Waespy· 2 shared N. Dinesh Kumar· 2 shared A. D. G. Lawson· 1 shared A. K. Agyapong· 1 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiochemistry

J. Rosenau

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Author profile →

6 papers

Recent·Most cited

N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase

J. Rosenau, I. L. Grothaus, Y. Yang, N. Dinesh Kumar, L. C. Ciacchi, S. Kelm, M. Waespy

This study shows that N-glycans on Trypanosoma congolense trans-sialidase affect substrate affinity but not conversion rate, with molecular dynamics revealing structural interactions that enhance enzyme function.

bioRxiv · Dec 13, 2021Biochemistry

The transmission of African Animal Trypanosomiasis (Nagana) in two districts in the forest zone of Ghana

A. Tweneboah, J. Rosenau, A. K. Agyapong, T. K. Addison, I. A. M. Mahamat, J. S. Weber, S. Kelm, K. Badu

This study investigates trypanosome prevalence and vector density in two Ghanaian districts, finding high infection rates in tsetse flies and pigs with T. congolense as the dominant species.

bioRxiv · Aug 11, 2021 · PreprintEvolutionary Biology

The chemical synthesis of knob domain antibody fragments

A. Macpherson, J. R. Birtley, R. J. Broadbridge, K. Brady, Y. Tang, C. Joyce, K. Saunders, G. Bogle, J. Horton, S. Kelm, R. D. Taylor, R. J. Franklin, M. D. Selby, M. Laabei, T. Wonfor, , A. D. G. Lawson

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

bioRxiv · Jun 16, 2021 · PreprintBiochemistry

Cooperativity of catalytic and lectin-like domain of T. congolense trans-sialidase modulates its catalytic activity

M. Waespy, T. T. Gbem, N. Dinesh Kumar, S. Solaiyappan Mani, J. Rosenau, F. Dietz, S. Kelm

This study shows that the lectin domain of T. congolense trans-sialidase modulates its catalytic activity by favoring trans-sialylation over hydrolysis when interacting with specific carbohydrates.

bioRxiv · May 28, 2021Biochemistry

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and Mice

A. Kovaltsuk, M. I. J. Raybould, W. K. Wong, C. Marks, S. Kelm, J. Snowden, J. Trück, C. M. Deane

The paper structurally characterizes B-cell receptor paratopes in humans and mice, showing structural differences across B-cell differentiation stages and conservation in naive repertoires.

bioRxiv · Sep 9, 2019Immunology

Observed Antibody Space: a resource for data mining next generation sequencing of antibody repertoires

A. Kovaltsuk, J. Leem, S. Kelm, J. Snowden, C. M. Deane, K. Krawczyk

The paper introduces a resource called Observed Antibody Space (OAS) that curates and provides access to over half a billion antibody sequences from 53 studies for immune repertoire analysis.

bioRxiv · May 19, 2018Immunology