G. Chandra

Identification of novel tail-anchored membrane proteins integrated by the bacterial twin-arginine translocase

The paper identifies novel tail-anchored Tat substrates in bacterial genomes through bioinformatics and experimental validation, revealing new iron-sulphur proteins and candidate substrates without cofactors.

Barley cultivars shape the abundance, phenotype, genotype and gene expression of their associated microbiota by differential root exudate secretion

Plasmid manipulation of bacterial behaviour through translational regulatory crosstalk

This paper identifies RsmQ as a plasmid translational regulator that globally controls bacterial behavior by altering the proteome, leading to a switch from motile to sessile lifestyle.

Genome-wide identification of the LexA-mediated DNA damage response in Streptomyces venezuelae

This study identifies the LexA-mediated DNA damage response in Streptomyces venezuelae using transcriptional profiling and ChIP-seq, revealing the regulon and DNA repair gene regulation.

Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition

The paper identifies specialized metabolites in Pseudomonas that inhibit potato pathogens in agricultural soil.

Hyphal compartmentalization and sporulation in Streptomyces require the conserved cell division protein SepX

This study identifies SepX as essential for cell division modes in Streptomyces venezuelae, showing its role in cross-wall formation and developmental progression.

Refactoring the formicamycin biosynthetic gene cluster to make high-level producing strains and new molecules

This paper refactors the formicamycin biosynthetic gene cluster to enhance production and generate new molecules by manipulating regulatory elements.

Second messenger control of mRNA translation by dynamic ribosome modification

This study shows that RimK modifies ribosomal protein RpsF in Pseudomonas fluorescens to regulate translation, with activity controlled by RimA, RimB, and cyclic-di-GMP.

Self-immunity guided identification of threonyl-tRNA synthetase as the molecular target of obafluorin, a β-lactone antibiotic

Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool

The paper introduces RiPPER, a tool for identifying RiPP precursor peptides, and uses it to discover new thioamidated RiPPs in Actinobacteria.

BldC delays entry into development to produce a sustained period of vegetative growth in Streptomyces venezuelae

This paper identifies BldC as a repressor of sporulation genes in Streptomyces venezuelae, showing it delays development to extend vegetative growth.

Discovery and biosynthesis of the antibiotic bicyclomycin in distant bacterial classes

This paper identifies the biosynthetic gene cluster for bicyclomycin in Streptomyces cinnamoneus and discovers its presence in hundreds of Pseudomonas aeruginosa isolates across different bacterial classes.

A unifying mechanism for the biogenesis of prokaryotic membrane proteins co-operatively integrated by the Sec and Tat pathways

This paper identifies a unifying mechanism for the biogenesis of prokaryotic membrane proteins that require both Sec and Tat pathways for insertion, showing that low hydrophobicity and C-terminal charges dictate Sec release.