The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
M. Duran-Ferrer, G. Clot, F. Nadeu, R. Beekman, T. Bauman, J. Nordlund, Y. Marincevic-Zuniga, G. Lonnerholm, A. Rivas, S. Martin, R. Ordonez, G. Castellano, M. Kulis, A. Queiros, L. Seung-Tae, , J. I. Martin-Subero
This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.
bioRxiv · Feb 6, 2020Cancer Biology