F. Prosper

Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling

This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

Uncovering the regulatory landscape of early human B-cell lymphopoiesis and its implications in the pathogenesis of B-cell acute lymphoblastic leukemia

This study characterizes the gene regulatory network of early human B-cell development and identifies regulatory elements linked to B-cell acute lymphoblastic leukemia.

In vivo generation of heart and vascular system by blastocyst complementation

This study generates transplantable hearts and vascular systems in mice using blastocyst complementation with exogenous cells, achieving viable organs with normal function and no rejection signs.

An Atlas of Cells in the Human Tonsil

The paper creates a comprehensive cell atlas of the human tonsil using single-cell multi-omics data, identifying 121 cell types and uncovering regulatory mechanisms and disease-related changes.

The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells

This study shows Sin3A regulates IL-17A and Foxp3 expression in CD4 T cells, affecting Th17 differentiation and immunoregulatory potential.

Revealing cell populations catching the early stages of the human embryo development in naive pluripotent stem cells

The paper identifies and characterizes distinct cell populations in naive human induced pluripotent stem cells that resemble early human embryo stages.

WAT3R: Recovery of T-Cell Receptor Variable Regions From 3' Single-Cell RNA-Sequencing

WAT3R recovers T-cell receptor variable regions from 3' scRNA-seq data, enabling T-cell clonotype reconstruction and analysis of TCR sequences in single cells.

Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of Dyserythropoiesis

This study identifies DDIT3 as a driver of dyserythropoiesis in MDS by showing its upregulation in HSCs and its ability to disrupt erythropoiesis when overexpressed.

A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

This study shows that a diabetic environment increases SARS-CoV-2 susceptibility in kidney organoids and patients by upregulating ACE2, which is critical for viral replication.

Deep deconvolution of the hematopoietic stem cell regulatory microenvironment reveals a high degree of specialization and conservation between mouse and human.

The paper develops a bioinformatic pipeline to analyze scRNA-seq data and identifies intermediate cell states and differentiation stages in the hematopoietic stem cell regulatory microenvironment, revealing conservation between mouse and human.

Renal proximal tubule cell state and metabolism are coupled by nuclear receptors

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

The paper identifies aberrant chromatin activation as a common mechanism driving the malignant phenotype in multiple myeloma.

Single-cell RNA-seq analysis reveals the crucial role of Collagen Triplex Helix Repeat Containing 1 (CTHRC1) cardiac fibroblasts for ventricular remodeling after myocardial infarction

This study identifies a pro-fibrotic fibroblast subpopulation in mice after myocardial infarction, showing CTHRC1's role in ventricular remodeling and cardiac function.