Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of Dyserythropoiesis
N. Berastegui, M. Ainciburu, J. P. Romero…·F. Prosper
This study identifies DDIT3 as a driver of dyserythropoiesis in MDS by showing its upregulation in HSCs and its ability to disrupt erythropoiesis when overexpressed.