Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and cell death
Z. Kabakci, S. Kaeppeli, G. Cozza, C. Cantu, C. Koenig, J. Toggweiler, C. Gentili, G. Ribaudo, G. Zagotto, K. Basler, L. A. Pinna, S. Ferrari
This study identifies CDC25 inhibitors that induce cell cycle arrest and cell death through a mixed-type mechanism, validated in 2D cultures and 3D organoids.
bioRxiv · Apr 27, 2018Cancer Biology