K. Basler

Activation of the innate immune system accelerates growth in cooperation with oncogenic Ras

This study shows that innate immune pathway activation can promote tumor growth when combined with oncogenic Ras in Drosophila.

Terminal differentiation of villus-tip enterocytes is governed by distinct members of Tgfβ superfamily

This study identifies distinct roles of Bmp2 and Tgfβ in driving specific enterocytic programs at different villus regions, with Bmp2 promoting terminal differentiation at the villus-tip.

Single-cell RNA sequencing unveils intestinal eosinophil development and specialization

The paper uses single-cell transcriptomics and flow cytometry to identify five eosinophil subsets in mice, revealing their developmental stages and specialized functions in the GI tract.

Discrete regulation of b-catenin-mediated transcription governs identity of intestinal epithelial stem cells

This study shows that discrete regulation of β-catenin-mediated transcription by co-factors determines the identity and proliferative behavior of intestinal epithelial stem cells.

Cryo-EM structure of the Hedgehog release protein Dispatched

This study presents the cryo-EM structure of Drosophila Dispatched, revealing its open conformation and unique Hh-binding mode, suggesting a receptor-chaperone role in Hedgehog release.

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and cell death

This study identifies CDC25 inhibitors that induce cell cycle arrest and cell death through a mixed-type mechanism, validated in 2D cultures and 3D organoids.