Identification of a Small Molecule Inhibitor of the Aminoglycoside 6’-N-Acetyltransferase Type Ib [AAC(6’)-Ib] Using Mixture-Based Combinatorial Libraries
T. Tran, K. Chiem, S. Jani, B. Arivett, D. Lin, R. Lad, V. Jimenez, M. Farone, G. Debevec, R. Santos, M. Giulianotti, C. Pinilla, M. Tolmasky
The paper identifies a small molecule inhibitor of AAC(6’)-Ib using combinatorial libraries and evaluates its efficacy against antibiotic-resistant bacteria.
bioRxiv · Oct 4, 2017Microbiology