T. Tran

TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway

This study shows that TOMM40 regulates lipid metabolism in hepatocytes through an LXR-dependent pathway, affecting plasma lipid levels and hepatic lipid droplet accumulation.

The impact of various microplastics on bacterial community and antimicrobial resistance genes in Norwegian and South African wastewater

This study examines how different microplastics affect bacterial communities and antimicrobial resistance genes in wastewater from Norway and South Africa.

Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib

This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.

Differential predictive value of resident memory CD8+T cell subpopulations in non-small-cell lung cancer patients treated by immunotherapy

The paper identifies two TRM subpopulations in NSCLC patients and shows that only DP TRM predicts response to PD-1 blockade immunotherapy.

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance

This paper quantifies the relationship between AAC(6')-Ib enzyme concentration and amikacin resistance in E. coli, showing a linear increase until a plateau due to protein aggregation.

Molecular Basis of Cell Membrane Adaptation in Daptomycin-Resistant Enterococcus faecalis

This study identifies the role of cardiolipin synthase and the LiaFSR system in daptomycin resistance by redistributing anionic phospholipids in Enterococcus faecalis.

A synthetic delivery vector for mucosal vaccination

This paper develops a synthetic delivery vector for mucosal vaccination that induces mucosal immunity and CD8+ T cell responses in mice.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

Genetic characterization of extended-beta-lactamase (ESBL) plasmids captured from dairy manures

This study characterizes ESBL-carrying plasmids from dairy manure using hybrid sequencing, revealing diversity in incompatibility groups, resistance genes, and mobile elements.

Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical antibiotic concentrations

This study determines the minimum selection concentrations of antibiotics for manure-originated multi-drug resistant plasmids in E. coli, showing they can be maintained in environmentally relevant concentrations.

Modeling Tick Populations: An Ecological Test Case forGradient Boosted Trees

This study compares gradient boosted trees and linear models in predicting blacklegged tick populations using environmental data, finding gradient boosted models more accurate and capable of capturing non-linear relationships.

Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

This study identifies a shared dimerization interface in MST kinases that is essential for trans-autophosphorylation and activation across species.

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

Circular single-stranded DNA is a superior homology-directed repair donor template for efficient genome engineering

This paper develops a non-viral system for efficient genome engineering using circular single-stranded DNA (cssDNA) donors, achieving high knock-in efficiency and improved safety compared to viral vectors.

Bacterial chemoreceptor signaling complexes control kinase activity by stabilizing the catalytic domain of CheA

This study investigates how bacterial chemoreceptor signaling complexes modulate CheA kinase activity through domain stabilization and destabilization during chemotaxis.

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

Activated MST2 kinase is free of kinetic regulation

This study presents a kinetic analysis of MST2 kinase activity, showing that once activated, its catalytic domain is free of regulation.

Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye

This study characterizes ocular biometrics and retinal function in rhesus macaques, finding similarities to human eyes, particularly in macular structure and cone photoreceptor function.

Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

Genetic characterization of AmpC and extended-spectrum beta-lactamase (ESBL) phenotypes in Escherichia coli and Salmonella from Alberta poultry

This study characterizes antimicrobial resistance genes in E. coli and Salmonella from poultry, identifying AmpC and ESBL phenotypes and their transferability via plasmids.

Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

This study shows that motor neurons enhance muscle stem cell function by boosting protein synthesis and mitochondrial activity, which is critical for muscle regeneration and is disrupted in diseases like muscular dystrophy and aging.

Spatial Transcriptional Mapping of the Human Nephrogenic Program

The paper spatially maps the human nephrogenic program using single-cell RNA sequencing and generates functional gene-networks to identify developmental disease genes and predict new targets.

Direct RNA sequencing and early evolution of SARS-CoV-2

The paper presents the first native RNA sequence of SARS-CoV-2, detailing its transcriptome and epitranscriptome, and infers genetic features and evolutionary rate.

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.

Alcohol increases aggression in flies

The paper identifies two pathways by which alcohol increases aggression in male flies: one through enhancing an olfactory pheromone and the other through systemic alcohol effects.

Lactic Acid Containing Polymers Produced in Engineered Sinorhizobium meliloti and Pseudomonas putida

This paper demonstrates the production of various biopolymers using a plasmid-based system in engineered bacterial strains.

Restoration of Susceptibility to Amikacin by 8-Hydroxyquinoline Analogs Complexed to Zinc

This study evaluates 8-hydroxyquinoline analogs complexed with zinc to restore amikacin susceptibility in AAC(6)-Ib-producing Acinetobacter baumannii strains.

DeepTRIAGE: Interpretable and Individualised BiomarkerScores using Attention Mechanism for the Classification of Breast Cancer Sub-types

DeepTRIAGE classifies breast cancer sub-types and assigns individualised biomarker scores using an attention mechanism, revealing heterogeneity within luminal sub-types.

Covalent Aurora A regulation by the metabolic integrator coenzyme A

This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.

Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit and Myonuclear- and Mitochondrial-Domains

This study investigates how critical limb ischemia affects skeletal muscle by increasing myonuclear number and mitochondrial content per myonucleus in mice.