Pharmacology & ToxicologybioRxiv
Predicting kinase inhibitors using bioactivity matrix derived informer sets
H. Zhang, S. S. Ericksen, C.-p. Lee…·M. A. Newton
The paper develops an informer-based ranking method to predict kinase inhibitor activity using chemogenomic data, outperforming traditional chemical diversity-based approaches in both retrospective and prospective tests.
DOI 10.1371/journal.pcbi.1006813