Author

N. Clementi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

N. Mancini· 8 shared E. Criscuolo· 5 shared M. Clementi· 5 shared M. Castelli· 3 shared R. A. Diotti· 3 shared A. Broggi· 2 shared B. Sposito· 2 shared F. Granucci· 2 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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8 shared papersImmunology

N. Mancini

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

SARS-CoV-2 Spike Affinity and Dynamics Exclude the Strict Requirement of an Intermediate Host

M. Castelli, L. Scietti, N. Clementi, M. Cavallaro, S. Faravelli, A. Pinnola, E. Criscuolo, R. A. Diotti, M. Clementi, F. Forneris, N. Mancini

This study shows SARS-CoV-2 and RaTG13 spikes have similar ACE2 binding affinities, suggesting minimal species barriers, and highlights SARS-CoV-2's optimized dynamics for human ACE2 engagement.

bioRxiv · Aug 11, 2021 · PreprintMicrobiology

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

M. Severa, R. A. Diotti, M. P. Etna, F. Rizzo, S. Fiore, D. Ricci, M. Iannetta, A. Sinigaglia, A. Lodi, N. Mancini, E. Criscuolo, M. Clementi, M. Andreoni, S. Balducci, L. Barzon, , E. Coccia

This study compares plasmacytoid dendritic cell (pDC) phenotype and type I IFN response in asymptomatic and severe COVID-19 patients, finding differences in pDC frequency, phenotype, and cytokine levels.

bioRxiv · Apr 17, 2021Immunology

A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

B. Storti, P. Quaranta, C. Di Primio, N. Clementi, N. Mancini, E. Criscuolo, P. G. Spezia, V. Carnicelli, G. Lottini, E. Paolini, G. Freer, M. Lai, M. Costa, F. Beltram, A. Diaspro, , R. Bizzarri

The paper uses multi-scale fluorescence microscopy to study SARS-CoV-2 variant entry into Vero E6 cells, finding B.1.1.7 enters faster than its ancestor due to the N501Y mutation.

bioRxiv · Mar 31, 2021Biophysics

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.

B. Sposito, A. Broggi, L. Pandolfi, S. Crotta, R. Ferrarese, S. Sisti, N. Clementi, A. Ambrosi, E. Liu, V. Frangipane, L. Saracino, L. Marongiu, F. Facchini, A. Bottazzi, T. Fossali, , I. Zanoni

This study examines IFN-I and IFN-III expression patterns in the respiratory tract of COVID-19 patients, finding higher IFN-III levels in severe cases and varying roles across anatomical sites.

bioRxiv · Mar 30, 2021 · PreprintImmunology

Maturation signatures of conventional dendritic cell subtypes in COVID-19 reflect direct viral sensing

L. Marongiu, G. Protti, F. A. Facchini, M. Valache, F. Mingozzi, V. Ranzani, A. R. Putignano, L. Salviati, V. Bevilacqua, S. Curti, M. Crosti, M. D'Angio, L. R. Bettini, A. Biondi, L. Nespoli, , F. Granucci

This study identifies maturation signatures of conventional dendritic cell subtypes in COVID-19, showing that cDC2s exhibit viral sensing and inflammatory activation while losing antigen presentation capacity, correlating with disease severity.

bioRxiv · Mar 3, 2021Immunology

A human stem cell-derived neurosensory-epithelial circuitry on-a-chip to model herpes simplex virus reactivation

P. G. Mazzara, E. Criscuolo, M. Rasponi, L. Massimino, S. Muggeo, C. Palma, M. Castelli, M. Clementi, R. Burioni, N. Mancini, V. Broccoli, N. Clementi

This study develops a human stem cell-derived neurosensory-epithelial circuitry on-a-chip to model HSV-1 reactivation and latency.

bioRxiv · Nov 19, 2020Microbiology

Type III interferons disrupt the lung epithelial barrier upon viral recognition.

A. Broggi, S. Ghosh, B. Sposito, R. Spreafico, F. Balzarini, A. Lo Cascio, N. Clementi, M. De Santis, N. Mancini, F. Granucci, I. Zanoni

This study shows that type III interferons from lung dendritic cells damage the epithelial barrier and increase susceptibility to bacterial infections during viral recognition.

bioRxiv · May 5, 2020Immunology

Combined prophylactic and therapeutic use maximizes hydroxychloroquine anti-SARS-CoV-2 effects in vitro

N. Clementi, E. Criscuolo, R. A. Diotti, R. Ferrarese, M. Castelli, R. Burioni, M. Clementi, N. Mancini

This study shows that hydroxychloroquine is most effective against SARS-CoV-2 when used both before and after infection in vitro.

bioRxiv · Mar 29, 2020Microbiology