ImmunologybioRxiv
High glucose enhances antigen-independent CTL killing via TRAIL
W. Yang, A. Denger, C. Diener…·B. Qu
This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.
DOI 10.3389/fimmu.2022.831680