D. Brenner

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

Glutathione supports lipid abundance in vivo

This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

This study identifies mitochondrial one-carbon metabolism as a key driver of cancer cell migration and metastasis independent of proliferation.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

High glucose enhances antigen-independent CTL killing via TRAIL

This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

This study shows that a low-fiber diet in SPF mice increases susceptibility to Citrobacter rodentium by altering gut microbiota and reducing mucosal barrier integrity.

DJ-1 depletion slows down immunoaging in T-cell compartments

This study shows that DJ-1 depletion delays immunoaging in T-cell compartments in both humans and mice by preserving non-senescent T cells and affecting hematopoietic and naive-CD8-intrinsic mechanisms.

MondoA Drives Malignancy in cALL through Enhanced Adaptation to Metabolic Stress

This study shows MondoA promotes malignancy in pediatric cALL by enhancing metabolic stress adaptation, with potential therapeutic implications.

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis

This study shows PARK7/DJ-1 enhances PDH activity in Tregs by inhibiting PDHA phosphorylation, maintaining Treg homeostasis and reducing EAE severity.

Cytogenetically-based biodosimetry after high doses of radiation

This study improves the CBMN assay for accurate dose reconstruction after high radiation doses by modifying checkpoint inhibition with caffeine and ZM447439.