Activation of the Crtc2/Creb1 transcriptional network in skeletal muscle enhances weight loss during intermittent fasting
N. Bruno, J. C. Nwachukwu, S. Srinivasan, D. Sturgill, G. Hager, S. Hurst, S.-S. Sheu, M. Conkright, K. W. Nettles
This study shows that Crtc2/Creb1 overexpression in skeletal muscle enhances mitochondrial function and promotes weight loss during intermittent fasting by improving metabolic flux and reversing fasting-induced mitochondrial downregulation.
bioRxiv · Jun 27, 2020 · PreprintPhysiology