Author

T. Izard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. C. Nwachukwu· 3 shared K. W. Nettles· 3 shared C. C. Nettles· 2 shared E. S. Rangarajan· 2 shared J. A. Katzenellenbogen· 2 shared J. Min· 2 shared R. Houtman· 2 shared S. H. Kim· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBiophysics

J. C. Nwachukwu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu

C. K. Min, J. C. Nwachukwu, Y. Hou, R. Russo, A. Papa, J. Min, R. Peng, S. H. Kim, Y. Zeigler, E. S. Rangarajan, T. Izard, B. S. Katzenellenbogen, J. A. Katzenellenbogen, K. W. Nettles

This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.

bioRxiv · Apr 10, 2024 · PreprintBiophysics

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L. Zhang, C. B. Jackson, H. Mou, A. Ojha, E. S. Rangarajan, T. Izard, M. Farzan, H. Choe

The paper compares the D614G mutation in SARS-CoV-2 spike protein, finding it reduces S1 shedding and increases infectivity without affecting ACE2 binding or neutralization.

Nature Communications · Nov 26, 2020Peer-reviewedMicrobiology

Dual mechanism estrogen receptor inhibitors

J. Min, J. C. Nwachukwu, S. Srinivasan, E. Rangarajan, C. C. Nettles, V. Sanabria Guillen, Y. Ziegler, S. Yan, K. Carlson, Y. Hou, S. H. Kim, S. Novick, B. Pascal, R. Houtman, P. Griffin, , K. W. Nettles

This paper develops dual-mechanism ER inhibitors that use two distinct targeting moieties to suppress ER activity in breast cancer cells and resistance models.

bioRxiv · Jul 6, 2020Cancer Biology

Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling

N. Bruno, J. C. Nwachukwu, S. Srinivasan, C. C. Nettles, T. Izard, z. Jin, S. Boregowda, D. Phinney, O. Elemento, X. Liu, E. A. Ortlund, R. Houtman, D. Stavreva, G. Hager, T. Kamencka, , K. W. Nettles

The paper uses Ligand Class Analysis to identify target genes and coregulator interactions of glucocorticoid receptor ligands, revealing mechanisms linking ligand structure to physiological outcomes.

bioRxiv · Jun 15, 2020Pharmacology & Toxicology