Necrosis triggered by Mycobacterium tuberculosis alters macrophage triglyceride metabolism and inflammatory response in a DGAT1-dependent manner
N. Jaisinghani, S. Dawa, K. Singh, A. Nandy, D. Menon, P. Bhandari, G. Khare, A. Tyagi, S. Gandotra
This study shows that M. tuberculosis-induced necrosis promotes triglyceride storage in macrophages, which enhances inflammation, and that DGAT1 plays a key role in this process.
bioRxiv · Sep 11, 2017Immunology